Can Blood Gene Expression Predict Which Patients with Multiple Sclerosis Will Respond to Interferon?
نویسندگان
چکیده
منابع مشابه
Can Blood Gene Expression Predict Which Patients with Multiple Sclerosis Will Respond to Interferon?
0105 Perspectives D espite the signifi cant progress in increasing our understanding of the immune mechanisms of multiple sclerosis (MS), in improving clinical classifi cation and brain imaging, and in developing new treatments, the factors that determine the course of the disease are mostly unknown [1]. Currently, it is nearly impossible to predict the course of MS, its severity in terms of di...
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Background: Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The present study aimed to compare hand dexterity of MS patients with low Expanded Disability Status Scale (EDSS) scores and healthy adults. It also sought to identify the predictors of disability status of patients with MS based on their m...
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interferon- gamma (ifn- γ) is an important immune regulator and inflammatory cytokine which is implicated in the pathogenesis of multiple sclerosis (ms). a single nucleotide polymorphism, t to a, at position +874 in the first intron has previously been shown. this polymorphism is associated with ifn- γ production level. to study the effect of this polymorphism on susceptibility to multiple scle...
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Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS. Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals. Materials & ...
متن کاملInterferon-gamma gene polymorphism in Iranian patients with multiple sclerosis.
Interferon- gamma (IFN- gamma) is an important immune regulator and inflammatory cytokine which is implicated in the pathogenesis of multiple sclerosis (MS). A single nucleotide polymorphism, T to A, at position +874 in the first intron has previously been shown. This polymorphism is associated with IFN- gamma production level. To study the effect of this polymorphism on susceptibility to multi...
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ژورنال
عنوان ژورنال: PLoS Medicine
سال: 2005
ISSN: 1549-1676
DOI: 10.1371/journal.pmed.0020033